Aberrant Sensory Gating of the Primary Somatosensory Cortex Contributes to the Motor Circuit Dysfunction in Paroxysmal Kinesigenic Dyskinesia

Aberrant Sensory Gating of the Primary Somatosensory Cortex Contributes to the Motor Circuit Dysfunction in Paroxysmal Kinesigenic Dyskinesia

Paroxysmal kinesigenic dyskinesia (PKD) is conventionally regarded as a movement disorder (MD) and characterized by episodic hyperkinesia by sudden movements. However, patients of PKD often have sensory aura and respond excellently to antiepileptic agents. PRRT2 mutations, the most common genetic et...

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Main Authors: Yo-Tsen Liu, Yi-Chieh Chen, Shang-Yeong Kwan, Chien-Chen Chou, Hsiang-Yu Yu, Der-Jen Yen, Kwong-Kum Liao, Wei-Ta Chen, Yung-Yang Lin, Rou-Shayn Chen, Kang-Yang Jih, Shu-Fen Lu, Yu-Te Wu, Po-Shan Wang, Fu-Jung Hsiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Neurology
Subjects:
paroxysmal kinesigenic dyskinesia
magnetoencephalagraphy
gamma oscillation
primary somatosensory cortex
PRRT2
sensory gating
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00831/full

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https://www.frontiersin.org/article/10.3389/fneur.2018.00831/full

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