Icotinib-resistant HCC827 cells produce exosomes with mRNA MET oncogenes and mediate the migration and invasion of NSCLC

Icotinib-resistant HCC827 cells produce exosomes with mRNA MET oncogenes and mediate the migration and invasion of NSCLC

Abstract Background Icotinib has been widely used in patients with non-small cell lung cancer (NSCLC), and have significantly enhanced the overall survival rate of NSCLC patients. However, acquired drug resistance limits its clinical efficacy. Tumor cell-derived exosomes have been reported to partic...

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Bibliographic Details
Main Authors: Yiming Yu, Maidinaimu Abudula, Chaofen Li, Zhongbo Chen, Yun Zhang, Yichen Chen
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Respiratory Research
Subjects:
Icotinib resistance
Exosomal MET
NSCLC
Migration and invasion
Online Access:http://link.springer.com/article/10.1186/s12931-019-1202-z

Internet

http://link.springer.com/article/10.1186/s12931-019-1202-z

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