The Small Rho GTPases Rac1 and Rac2 Are Important for T-Cell Independent Antigen Responses and for Suppressing Switching to IgG2b in Mice

The Small Rho GTPases Rac1 and Rac2 Are Important for T-Cell Independent Antigen Responses and for Suppressing Switching to IgG2b in Mice

The Rho GTPases Cdc42, Rac1, and Rac2 coordinate receptor signaling to cell adhesion, migration, and proliferation. Deletion of Rac1 and Rac2 early during B cell development leads to failure in B cell entry into the splenic white pulp. Here, we sought to understand the role of Rac1 and Rac2 in B cel...

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Bibliographic Details
Main Authors: Natalija Gerasimčik, Minghui He, Carin I. M. Dahlberg, Nikolai V. Kuznetsov, Eva Severinson, Lisa S. Westerberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
B cells
Rac1
Rac2
Ig class switching
humoral immune response
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01264/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01264/full

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