HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

HIV-1 replication commences inside the cone-shaped viral capsid, but timing, localization, and mechanism of uncoating are under debate. We adapted a strategy to visualize individual reverse-transcribed HIV-1 cDNA molecules and their association with viral and cellular proteins using fluorescence and...

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Bibliographic Details
Main Authors: Thorsten G Müller, Vojtech Zila, Kyra Peters, Sandra Schifferdecker, Mia Stanic, Bojana Lucic, Vibor Laketa, Marina Lusic, Barbara Müller, Hans-Georg Kräusslich
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
HIV-1
uncoating
reverse transcription
DNA labeling
live cell imaging
CLEM
Online Access:https://elifesciences.org/articles/64776

Internet

https://elifesciences.org/articles/64776

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