Roles for Cell-Cell Adhesion and Contact in Obesity-Induced Hepatic Myeloid Cell Accumulation and Glucose Intolerance

Roles for Cell-Cell Adhesion and Contact in Obesity-Induced Hepatic Myeloid Cell Accumulation and Glucose Intolerance

Obesity promotes infiltration of inflammatory cells into various tissues, leading to parenchymal and stromal cell interaction and development of cellular and organ dysfunction. Liver sinusoidal endothelial cells (LSECs) are the first cells that contact portal blood cells and substances in the liver,...

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Bibliographic Details
Main Authors: Yasutaka Miyachi, Kyoichiro Tsuchiya, Chikara Komiya, Kumiko Shiba, Noriko Shimazu, Shinobu Yamaguchi, Michiyo Deushi, Mizuko Osaka, Kouji Inoue, Yuta Sato, Sayaka Matsumoto, Junichi Kikuta, Kenjiro Wake, Masayuki Yoshida, Masaru Ishii, Yoshihiro Ogawa
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
insulin resistance
inflammation
obesity
diabetes
macrophages
neutrophils
monocytes
Notch signaling
liver sinusoidal endothelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302371

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http://www.sciencedirect.com/science/article/pii/S2211124717302371

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