Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β

Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β

The various symptomatic outcomes of cutaneous leishmaniasis relates to the type and potency of its underlying inflammatory responses. Presence of the cytoplasmic Leishmania RNA virus-1 (LRV1) within Leishmania guyanensis, worsens lesional inflammation and parasite burden, as the viral dsRNA genome a...

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Bibliographic Details
Main Authors: Mary-Anne Hartley, Remzi O. Eren, Matteo Rossi, Florence Prevel, Patrik Castiglioni, Nathalie Isorce, Chantal Desponds, Lon-Fye Lye, Stephen M. Beverley, Stefan K. Drexler, Nicolas Fasel
Format: Article
Language:English
Published: Shared Science Publishers OG 2018-01-01
Series:Microbial Cell
Subjects:
Leishmania
Leishmania-virus
metastatic leishmaniasis
inflammasome
NOD-like receptors
RIG-like receptors
A20
Online Access:http://microbialcell.com/researcharticles/leishmania-guyanensis-parasites-block-the-activation-of-the-inflammasome-by-inhibiting-maturation-of-il-1%ce%b2/

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http://microbialcell.com/researcharticles/leishmania-guyanensis-parasites-block-the-activation-of-the-inflammasome-by-inhibiting-maturation-of-il-1%ce%b2/

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