Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis

Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis

Abstract Background Hypercholesterolemia has posed a serious threat of heart diseases and stroke worldwide. Xanthine oxidase (XO), the rate-limiting enzyme in uric acid biosynthesis, is regarded as the root of reactive oxygen species (ROS) that generate atherosclerosis and cholesterol crystals. β-Hy...

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Bibliographic Details
Main Authors: Rishab Marahatha, Saroj Basnet, Bibek Raj Bhattarai, Prakriti Budhathoki, Babita Aryal, Bikash Adhikari, Ganesh Lamichhane, Darbin Kumar Poudel, Niranjan Parajuli
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Natural products
Molecular docking
Cholesterol
Enzyme inhibition
Online Access:https://doi.org/10.1186/s12906-020-03162-5

Internet

https://doi.org/10.1186/s12906-020-03162-5

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