Calpains of Leishmania braziliensis: genome analysis, differential expression, and functional analysis

BACKGROUND Calpains are proteins belonging to the multi-gene family of calcium-dependent cysteine peptidases that undergo tight on/off regulation, and uncontrolled proteolysis of calpains is associated with severe human pathologies. Calpain orthologues are expanded and diversified in the trypanosom...

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Main Authors: Vítor Ennes-Vidal, Bianca da Silva Vitório, Rubem Figueiredo Sadok Menna-Barreto, André Nóbrega Pitaluga, Silvia Amaral Gonçalves-da-Silva, Marta Helena Branquinha, André Luis Souza Santos, Claudia Masini d’Avila-Levy
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde
Series:Memórias do Instituto Oswaldo Cruz.
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Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100347&lng=en&tlng=en