Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor

Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor

Factor VIII (fVIII) is a procoagulant protein that binds to activated factor IX (fIXa) on platelet surfaces to form the intrinsic tenase complex. Due to the high immunogenicity of fVIII, generation of antibody inhibitors is a common occurrence in patients during hemophilia A treatment and spontaneou...

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Bibliographic Details
Main Authors: Estelle K. Ronayne, Shaun C. Peters, Joseph S. Gish, Celena Wilson, H. Trent Spencer, Christopher B. Doering, Pete Lollar, P. Clint Spiegel, Kenneth C. Childers
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
factor VIII
blood coagulation
x-ray crystallography
antibody inhibitors
antibody binding
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.697602/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.697602/full

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