An Integrated Bioinformatics Analysis Repurposes an Antihelminthic Drug Niclosamide for Treating HMGA2-Overexpressing Human Colorectal Cancer

An Integrated Bioinformatics Analysis Repurposes an Antihelminthic Drug Niclosamide for Treating HMGA2-Overexpressing Human Colorectal Cancer

Aberrant overexpression of high mobility group AT-hook 2 (HMGA2) is frequently found in cancers and HMGA2 has been considered an anticancer therapeutic target. In this study, a pan-cancer genomics survey based on Cancer Cell Line Encyclopedia (CCLE) and The Cancer Genome Atlas (TCGA) data indicated...

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Bibliographic Details
Main Authors: Stephen Wan Leung, Chia-Jung Chou, Tsui-Chin Huang, Pei-Ming Yang
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
bioinformatics
connectivity map
colorectal cancer
drug repurposing
hmga2
s100a4
Online Access:https://www.mdpi.com/2072-6694/11/10/1482

Internet

https://www.mdpi.com/2072-6694/11/10/1482

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