Bone tumor–targeted delivery of theranostic 195mPt-bisphosphonate complexes promotes killing of metastatic tumor cells

Bone tumor–targeted delivery of theranostic 195mPt-bisphosphonate complexes promotes killing of metastatic tumor cells

Platinum-based drugs such as cisplatin are very potent chemotherapeutics, whereas radioactive platinum (195mPt) is a rich source of low-energy Auger electrons, which kills tumor cells by damaging DNA. Auger electrons damage cells over a very short range. Consequently, 195mPt-based radiopharmaceutica...

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Bibliographic Details
Main Authors: R.A. Nadar, G.M. Franssen, N.W.M. Van Dijk, K. Codee-van der Schilden, M. de Weijert, E. Oosterwijk, M. Iafisco, N. Margiotta, S. Heskamp, J.J.J.P. van den Beucken, S.C.G. Leeuwenburgh
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Materials Today Bio
Subjects:
195m-platinum
Bone-targeting
Bone metastases
Auger therapy
Theranostics
Online Access:http://www.sciencedirect.com/science/article/pii/S259000642030048X

Internet

http://www.sciencedirect.com/science/article/pii/S259000642030048X

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