NS5806 Induces Electromechanically Discordant Alternans and Arrhythmogenic Voltage-Calcium Dynamics in the Isolated Intact Rabbit Heart

NS5806 Induces Electromechanically Discordant Alternans and Arrhythmogenic Voltage-Calcium Dynamics in the Isolated Intact Rabbit Heart

Background: NS5806 activates the transient outward potassium current Ito, and has been claimed to reproduce Brugada Syndrome (BrS) in ventricular wedge preparations. Ito modulates excitation-contraction coupling, which is critical in alternans dynamics. We explored NS5806-arrhythmogenic effects in t...

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Bibliographic Details
Main Authors: Sufen Wang, Moisés Rodríguez-Mañero, Sergio H. Ibarra-Cortez, Bahij Kreidieh, Laura Valderrábano, Majd Hemam, Liliana Tavares, Elvin Blanco, Miguel Valderrábano
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Physiology
Subjects:
NS5806
Brugada syndrome
alternans
calcium cycling
ventricular fibrillation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01509/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01509/full

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