Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells

Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells

<p>Abstract</p> <p>Background</p> <p>The mammalian target of rapamycin (mTOR) is frequently activated in colon cancers due to mutations in the phosphatidylinositol 3-kinase (PI3K) pathway. Targeting mTOR with allosteric inhibitors of mTOR such as rapamycin reduces colon...

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Bibliographic Details
Main Authors: Blaser Benjamin, Waselle Laurent, Dormond-Meuwly Anne, Dufour Marc, Roulin Didier, Demartines Nicolas, Dormond Olivier
Format: Article
Language:English
Published: BMC 2012-03-01
Series:BMC Cancer
Subjects:
Colon cancer
mTOR
Rapamycin
NVP-BEZ235
PP242
Proliferation
Xenograft
Online Access:http://www.biomedcentral.com/1471-2407/12/86

Internet

http://www.biomedcentral.com/1471-2407/12/86

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