Elucidation of Inverse Agonist Activity of Bilastine

Elucidation of Inverse Agonist Activity of Bilastine

H<sub>1</sub>-antihistamines antagonize histamine and prevent it from binding to the histamine H<sub>1</sub> receptor (H1R). Some of them also act as inverse agonists, which are more potent than pure antagonists because they suppress the constitutive H1R activity. Bilastine i...

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Bibliographic Details
Main Authors: Hiroyuki Mizuguchi, Tomoharu Wakugawa, Hisato Sadakata, Seiichiro Kamimura, Mai Takemoto, Tomomi Nakagawa, Masami Yabumoto, Yoshiaki Kitamura, Noriaki Takeda, Hiroyuki Fukui
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pharmaceutics
Subjects:
H<sub>1</sub>-antihistamines
histamine H<sub>1</sub> receptor gene expression
inositol phosphates accumulation
inverse agonist
time-laps Ca<sup>2+</sup> imaging
Online Access:https://www.mdpi.com/1999-4923/12/6/525

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https://www.mdpi.com/1999-4923/12/6/525

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