The oncometabolite R-2-hydroxyglutarate dysregulates the differentiation of human mesenchymal stromal cells via inducing DNA hypermethylation

The oncometabolite R-2-hydroxyglutarate dysregulates the differentiation of human mesenchymal stromal cells via inducing DNA hypermethylation

Abstract Background Isocitrate dehydrogenase (IDH1/2) gene mutations are the most frequently observed mutations in cartilaginous tumors. The mutant IDH causes elevation in the levels of R-enantiomer of 2-hydroxylglutarate (R-2HG). Mesenchymal stromal cells (MSCs) are reasonable precursor cell candid...

Full description

Bibliographic Details
Main Authors: Lizhen Liu, Kaimin Hu, Jingjing Feng, Huafang Wang, Shan Fu, Binsheng Wang, Limengmeng Wang, Yulin Xu, Xiaohong Yu, He Huang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Cancer
Subjects:
R-2-hydroxyglutarate
IDH mutation
Mesenchymal stromal cells
Differentiation
DNA hypermethylation
Online Access:https://doi.org/10.1186/s12885-020-07744-x

Internet

https://doi.org/10.1186/s12885-020-07744-x

Similar Items