Human apolipoprotein C-I expression in mice impairs learning and memory functions

Human apolipoprotein C-I expression in mice impairs learning and memory functions

The H2 allele of APOC1, giving rise to increased gene expression of apolipoprotein C-I (apoC-I), is in genetic disequilibrium with the APOE4 allele and may provide a major risk factor for Alzheimer's disease (AD). We found that apoC-I protein is present in astrocytes and endothelial cells withi...

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Bibliographic Details
Main Authors: Karlygash Abildayeva, Jimmy F.P. Berbée, Arjan Blokland, Paula J. Jansen, Frans J. Hoek, Onno Meijer, Dieter Lütjohann, Thomas Gautier, Thierry Pillot, Jan De Vente, Louis M. Havekes, Frans C.S. Ramaekers, Folkert Kuipers, Patrick C.N. Rensen, Monique Mulder
Format: Article
Language:English
Published: Elsevier 2008-04-01
Series:Journal of Lipid Research
Subjects:
Alzheimer's disease
apolipoprotein E
object recognition task
Morris water maze task
β-amyloid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520423995

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http://www.sciencedirect.com/science/article/pii/S0022227520423995

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