5-Episinuleptolide Acetate, a Norcembranoidal Diterpene from the Formosan Soft Coral Sinularia sp., Induces Leukemia Cell Apoptosis through Hsp90 Inhibition

5-Episinuleptolide Acetate, a Norcembranoidal Diterpene from the Formosan Soft Coral Sinularia sp., Induces Leukemia Cell Apoptosis through Hsp90 Inhibition

5-Episinuleptolide acetate (5EPA), a cytotoxic norcembranoidal diterpene recently identified from the Formosan soft coral Sinularia sp., exhibited potent activity against the K562, Molt 4 and HL 60 cancer cell lines. The antiproliferative assay, as well as the annexin V-FITC/propidium iodide (PI) ap...

Full description

Bibliographic Details
Main Authors: Yao-Tsung Yeh, Wen-Been Chang, Yin-Di Su, Wei-Hsuan Yen, Chia-Wei Tsao, Jui-Hsin Su, Ying-Chi Du, Mohamed El-Shazly, Kao-Jean Huang, Yu-Cheng Chen, Mei-Chin Lu
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Molecules
Subjects:
5-episinuleptolide acetate
apoptosis
soft coral
Hsp90
mitochondria
ROS
Sinularia sp.
Online Access:http://www.mdpi.com/1420-3049/18/3/2924

Internet

http://www.mdpi.com/1420-3049/18/3/2924

Similar Items