The biological function of the cellular prion protein: an update

The biological function of the cellular prion protein: an update

Abstract The misfolding of the cellular prion protein (PrPC) causes fatal neurodegenerative diseases. Yet PrPC is highly conserved in mammals, suggesting that it exerts beneficial functions preventing its evolutionary elimination. Ablation of PrPC in mice results in well-defined structural and funct...

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Bibliographic Details
Main Authors:	Marie-Angela Wulf, Assunta Senatore, Adriano Aguzzi
Format:	Article
Language:	English
Published:	BMC 2017-05-01
Series:	BMC Biology
Subjects:	Prion Disease Metabotropic Glutamate Receptor Cellular Prion Protein Prnp Gene Flexible Tail
Online Access:	http://link.springer.com/article/10.1186/s12915-017-0375-5

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