Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration

Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration

Unlike canonical macroautophagy, alternative autophagy does not require the factors Atg5 and Atg7. Here, the authors show that Wipi3 is essential for alternative autophagy, but not for canonical autophagy, and that Wipi3 functions to maintain neuronal cells via mechanisms different from those of can...

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Bibliographic Details
Main Authors: Hirofumi Yamaguchi, Shinya Honda, Satoru Torii, Kimiko Shimizu, Kaoru Katoh, Koichi Miyake, Noriko Miyake, Nobuhiro Fujikake, Hajime Tajima Sakurai, Satoko Arakawa, Shigeomi Shimizu
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18892-w

Internet

https://doi.org/10.1038/s41467-020-18892-w

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