Inhibition of FEN1 Increases Arsenic Trioxide-Induced ROS Accumulation and Cell Death: Novel Therapeutic Potential for Triple Negative Breast Cancer

Inhibition of FEN1 Increases Arsenic Trioxide-Induced ROS Accumulation and Cell Death: Novel Therapeutic Potential for Triple Negative Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, which is very difficult to treat and commonly develops resistance to chemotherapy. The following study investigated whether the inhibition of Flap Endonuclease 1 (FEN1) expression, the key enzyme in the base excision rep...

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Bibliographic Details
Main Authors: Xing Xin, Ti Wen, Li-Bao Gong, Ming-Ming Deng, Ke-Zuo Hou, Lu Xu, Sha Shi, Xiu-Juan Qu, Yun-Peng Liu, Xiao-Fang Che, Yue-E Teng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
FEN1
ROS
arsenic trioxide
GSH
Nrf2
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00425/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00425/full

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