A Novel Compound Targeting Protease Receptor 1 Activators for the Treatment of Glioblastoma

A Novel Compound Targeting Protease Receptor 1 Activators for the Treatment of Glioblastoma

Data from human biopsies, in-vitro and in-vivo models, strongly supports the role of thrombin, and its protease-activated receptor (PAR1) in the pathology and progression of glioblastoma (GBM), a high-grade glial tumor. Activation of PAR1 by thrombin stimulates vasogenic edema, tumor adhesion and tu...

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Main Authors: Efrat Shavit-Stein, Ehud Sheinberg, Valery Golderman, Shirley Sharabi, Anton Wohl, Shany Guly Gofrit, Zion Zivli, Natalia Shelestovich, David Last, David Guez, Dianne Daniels, Orna Gera, Kate Feingold, Zeev Itsekson-Hayosh, Nurit Rosenberg, Ilia Tamarin, Amir Dori, Nicola Maggio, Yael Mardor, Joab Chapman, Sagi Harnof
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Neurology
Subjects:
glioblastoma
thrombin receptor
PAR1
tumor size
edema
survival
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.01087/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.01087/full

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