Interleukin-27 Enforces Regulatory T Cell Functions to Prevent Graft-versus-Host Disease

Interleukin-27 Enforces Regulatory T Cell Functions to Prevent Graft-versus-Host Disease

Graft-versus-host disease (GvHD) remains a significant complication of allogeneic hematopoietic cell transplantation (HCT), associated with significant morbidity and mortality. GvHD is characterized by dysregulated immune responses and resulting tissue damage of target organs. Recent investigations...

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Bibliographic Details
Main Authors: Hongnga T. Le, Karen Keslar, Quang Tam Nguyen, Bruce R. Blazar, Betty K. Hamilton, Booki Min
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
adoptive transfer
GvHD
IL-27
regulatory T cell
xenogeneic GvHD
transplantation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00181/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00181/full

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