The C289G and C418R missense mutations cause rapid sequestration of human Parkin into insoluble aggregates

The C289G and C418R missense mutations cause rapid sequestration of human Parkin into insoluble aggregates

Mutations in the parkin gene are responsible for autosomal recessive parkinsonism. The disease-linked missense mutations are highly concentrated in the RING–IBR–RING domains of Parkin. In this study, we investigated the consequences of several missense parkin gene mutations in cell culture. We have...

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Bibliographic Details
Main Authors: Wen-Jie Gu, Olga Corti, Francisco Araujo, Cornelia Hampe, Sandrine Jacquier, Christoph B Lücking, Nacer Abbas, Charles Duyckaerts, Thomas Rooney, Laurent Pradier, Merle Ruberg, Alexis Brice
Format: Article
Language:English
Published: Elsevier 2003-12-01
Series:Neurobiology of Disease
Subjects:
Parkin
Mutagenesis
Ubiquitin–proteasome system
Aggregation
Autosomal recessive juvenile parkinsonism
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103001529

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http://www.sciencedirect.com/science/article/pii/S0969996103001529

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