Mood Regulatory Actions of Active and Sham Nucleus Accumbens Deep Brain Stimulation in Antidepressant Resistant Rats

Mood Regulatory Actions of Active and Sham Nucleus Accumbens Deep Brain Stimulation in Antidepressant Resistant Rats

The antidepressant actions of deep brain stimulation (DBS) are associated with progressive neuroadaptations within the mood network, modulated in part, by neurotrophic mechanisms. We investigated the antidepressant-like effects of chronic nucleus accumbens (NAc) DBS and its association with change i...

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Bibliographic Details
Main Authors: Rajas P. Kale, Thanh Thanh L. Nguyen, J. Blair Price, Nathanael J. Yates, Ken Walder, Michael Berk, Roy V. Sillitoe, Abbas Z. Kouzani, Susannah J. Tye
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Human Neuroscience
Subjects:
deep brain stimualtion
nucleus accumbens
GSK3—glycogen synthase kinase 3
rodent
mTOR—mammalian target of rapamycin
mood
Online Access:https://www.frontiersin.org/articles/10.3389/fnhum.2021.644921/full

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https://www.frontiersin.org/articles/10.3389/fnhum.2021.644921/full

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