Biotin-Labelled Clavulanic Acid to Identify Proteins Target for Haptenation in Serum: Implications in Allergy Studies

Biotin-Labelled Clavulanic Acid to Identify Proteins Target for Haptenation in Serum: Implications in Allergy Studies

Clavulanic acid (CLV) and amoxicillin, frequently administered in combination, can be independently involved in allergic reactions. Protein haptenation with β-lactams is considered necessary to activate the immune system. The aim of this study was to assess the suitability of biotinylated analogues...

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Bibliographic Details
Main Authors: Ángela Martín-Serrano, Juan M. Gonzalez-Morena, Nekane Barbero, Adriana Ariza, Francisco J. Sánchez Gómez, Ezequiel Pérez-Inestrosa, Dolores Pérez-Sala, Maria J. Torres, María I. Montañez
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Pharmacology
Subjects:
betalactam
biotin tag
biotinylation
clavulanate
drug allergy
haptenation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.594755/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.594755/full

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