Enhancement of asymmetric bioreduction of N,N-dimethyl-3-keto-3-(2-thienyl)-1-propanamine to corresponding (S)-enantiomer by fusion of carbonyl reductase and glucose dehydrogenase

Enhancement of asymmetric bioreduction of N,N-dimethyl-3-keto-3-(2-thienyl)-1-propanamine to corresponding (S)-enantiomer by fusion of carbonyl reductase and glucose dehydrogenase

Abstract Background (S)-(−)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine (DHTP) is a key intermediate for the preparation of (S)-duloxetine, an important antidepressant drug. However, so far, the catalytic efficiency of (S)-DHTP synthesis by asymmetric bioreduction is yet limited. The present...

Full description

Bibliographic Details
Main Authors: Taiqiang Sun, Bin Li, Yao Nie, Dong Wang, Yan Xu
Format: Article
Language:English
Published: SpringerOpen 2017-05-01
Series:Bioresources and Bioprocessing
Subjects:
Asymmetric reduction
Carbonyl reductase
Glucose dehydrogenase
Fusion enzyme
Cofactor regeneration
Online Access:http://link.springer.com/article/10.1186/s40643-017-0151-y

Internet

http://link.springer.com/article/10.1186/s40643-017-0151-y

Similar Items