Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect.

Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect.

BACKGROUND: Epstein-Barr virus (EBV) encodes six nuclear transformation-associated proteins that induce extensive changes in cellular gene expression and signaling and induce B-cell transformation. The role of HIF1A in EBV-induced B-cell immortalization has not been previously studied. METHODS AND F...

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Bibliographic Details
Main Authors: Suhas Darekar, Konstantinos Georgiou, Mariya Yurchenko, Surya Pavan Yenamandra, Georgia Chachami, George Simos, George Klein, Elena Kashuba
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3407085?pdf=render

Internet

http://europepmc.org/articles/PMC3407085?pdf=render

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