Vectofusin-1, a New Viral Entry Enhancer, Strongly Promotes Lentiviral Transduction of Human Hematopoietic Stem Cells

Vectofusin-1, a New Viral Entry Enhancer, Strongly Promotes Lentiviral Transduction of Human Hematopoietic Stem Cells

Gene transfer into hCD34+ hematopoietic stem/progenitor cells (HSCs) using human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors (LVs) has several promising therapeutic applications. Yet, efficiency, safety, and cost of LV gene therapy could be ameliorated by enhancing target cell tra...

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Bibliographic Details
Main Authors: David Fenard, Dina Ingrao, Ababacar Seye, Julien Buisset, Sandrine Genries, Samia Martin, Antoine Kichler, Anne Galy
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
cationic peptide
gene therapy
hematopoietic stem cell
lentiviral vector
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301494

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http://www.sciencedirect.com/science/article/pii/S2162253116301494

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