Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents

Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents

In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2a–s were synthesized and evaluated for their antidepressant-like activity by tail suspension test (TST) and modified forced swimming test (MFST). The effects of the compounds on spontaneous locomotor activity were also...

Full description

Bibliographic Details
Main Authors: Ahmet Özdemir, Mehlika Dilek Altıntop, Zafer Asım Kaplancıklı, Özgür Devrim Can, Ümide Demir Özkay, Gülhan Turan-Zitouni
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:Molecules
Subjects:
pyrazoline
antidepressant activity
tail suspension test
modified forced swimming test
activity cage
Online Access:http://www.mdpi.com/1420-3049/20/2/2668

Internet

http://www.mdpi.com/1420-3049/20/2/2668

Similar Items