Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs

Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs

In eukaryotes, 43S preinitiation complex (PIC) formation is a rate-determining step of translation. Ribosome recycling following translation termination produces free 40S subunits for re-assembly of 43S PICs. Yeast mutants lacking orthologs of mammalian eIF2D (Tma64), and either MCT-1 (Tma20) or DEN...

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Bibliographic Details
Main Authors: Swati Gaikwad, Fardin Ghobakhlou, David J Young, Jyothsna Visweswaraiah, Hongen Zhang, Alan G Hinnebusch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
yeast
translation
initiation
ribosome
recycling
eIF2
Online Access:https://elifesciences.org/articles/64283

Internet

https://elifesciences.org/articles/64283

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