7-Deazaguanine modifications protect phage DNA from host restriction systems

7-Deazaguanine modifications protect phage DNA from host restriction systems

Viral genomic DNA is often modified to evade the host bacterial restriction system. Here the authors identified 2′-deoxy-7-deazaguanine modifications on phage DNA by comparative genomics and experimental validation, showing their role in genome protection.

Bibliographic Details
Main Authors: Geoffrey Hutinet, Witold Kot, Liang Cui, Roman Hillebrand, Seetharamsingh Balamkundu, Shanmugavel Gnanakalai, Ramesh Neelakandan, Alexander B. Carstens, Chuan Fa Lui, Denise Tremblay, Deborah Jacobs-Sera, Mandana Sassanfar, Yan-Jiun Lee, Peter Weigele, Sylvain Moineau, Graham F. Hatfull, Peter C. Dedon, Lars H. Hansen, Valérie de Crécy-Lagard
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13384-y

Internet

https://doi.org/10.1038/s41467-019-13384-y

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