TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

Summary: The aberrant expression of squamous lineage markers in pancreatic ductal adenocarcinoma (PDA) has been correlated with poor clinical outcomes. However, the functional role of this putative transdifferentiation event in PDA pathogenesis remains unclear. Here, we show that expression of the t...

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Bibliographic Details
Main Authors: Tim D.D. Somerville, Yali Xu, Koji Miyabayashi, Hervé Tiriac, Cristian R. Cleary, Diogo Maia-Silva, Joseph P. Milazzo, David A. Tuveson, Christopher R. Vakoc
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718316401

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http://www.sciencedirect.com/science/article/pii/S2211124718316401

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