Modeling Rett Syndrome with Human Pluripotent Stem Cells: Mechanistic Outcomes and Future Clinical Perspectives

Modeling Rett Syndrome with Human Pluripotent Stem Cells: Mechanistic Outcomes and Future Clinical Perspectives

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the gene encoding the methyl-CpG-binding protein 2 (MeCP2). Among many different roles, MeCP2 has a high phenotypic impact during the different stages of brain development. Thus, it is essential to intensively investigate th...

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Bibliographic Details
Main Authors: Ana Rita Gomes, Tiago G. Fernandes, Joaquim M.S. Cabral, Maria Margarida Diogo
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
Rett syndrome
MeCP2
neurodevelopmental disorders
hPSCs
hiPSCs
2D models
Online Access:https://www.mdpi.com/1422-0067/22/7/3751

Internet

https://www.mdpi.com/1422-0067/22/7/3751

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