Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones

Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones

A presynaptic adhesion G-protein-coupled receptor, latrophilin-1, and a postsynaptic transmembrane protein, Lasso/teneurin-2, are implicated in trans-synaptic interaction that contributes to synapse formation. Surprisingly, during neuronal development, a substantial proportion of Lasso is released i...

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Bibliographic Details
Main Authors: Nickolai V Vysokov, John-Paul Silva, Vera G Lelianova, Jason Suckling, John Cassidy, Jennifer K Blackburn, Natalia Yankova, Mustafa BA Djamgoz, Serguei V Kozlov, Alexander G Tonevitsky, Yuri A Ushkaryov
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
axon attraction
axon guidance
teneurin
Lasso
latrophilin
growth cone
Online Access:https://elifesciences.org/articles/37935

Internet

https://elifesciences.org/articles/37935

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