17β-Estradiol reduces tumor necrosis factor-α-mediated LDL accumulation in the artery wall

Estrogens have direct effects on the vascular wall that may prevent the development of atherosclerosis. In particular, estrogens, such as 17β-estradiol (estradiol), are known to have potent antioxidant activity. Tumor necrosis factor-α (TNF) is found in human atheroma and produces oxygen-derived fre...

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Bibliographic Details
Main Authors: Barbara A. Walsh, Adam E. Mullick, Rosemary L. Walzem, John C. Rutledge
Format: Article
Language:English
Published: Elsevier 1999-03-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520324421