BRCA1 Mutation Status and Follicular Fluid Exposure Alters NFκB Signaling and ISGylation in Human Fallopian Tube Epithelial Cells

BRCA1 Mutation Status and Follicular Fluid Exposure Alters NFκB Signaling and ISGylation in Human Fallopian Tube Epithelial Cells

Germline BRCA1 or BRCA2 mutations (mtBRCA1 and mtBRCA2) increase risk for high-grade serous ovarian cancer (HGSOC), the most commonly diagnosed epithelial ovarian cancer histotype. Other identified risk factors for this cancer, which originates primarily in the distal fallopian tube epithelium (FTE)...

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Bibliographic Details
Main Authors: Julia Hollingsworth, Angela Lau, Alicia Tone, Alexandra Kollara, Lisa Allen, Terence J. Colgan, Valerie Dube, Barry Rosen, K. Joan Murphy, Ellen M. Greenblatt, Tomer Feigenberg, Carl Virtanen, Theodore J. Brown
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S147655861830215X

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http://www.sciencedirect.com/science/article/pii/S147655861830215X

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