Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution

Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution

Imaging mass spectrometry is a powerful emerging tool for mapping the spatial distribution of biomolecules across tissue surfaces. Here the authors showcase an automated technology for deep proteome imaging that utilizes ultrasensitive microfluidics and a mass spectrometry workflow to analyze tissue...

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Bibliographic Details
Main Authors: Paul D. Piehowski, Ying Zhu, Lisa M. Bramer, Kelly G. Stratton, Rui Zhao, Daniel J. Orton, Ronald J. Moore, Jia Yuan, Hugh D. Mitchell, Yuqian Gao, Bobbie-Jo M. Webb-Robertson, Sudhansu K. Dey, Ryan T. Kelly, Kristin E. Burnum-Johnson
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13858-z

Internet

https://doi.org/10.1038/s41467-019-13858-z

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