Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis

Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis

There is increasing interest in the association between depression and the development of metabolic diseases. Rosiglitazone, a therapeutic drug used to treat type 2 diabetes mellitus, has shown neuroprotective effects in patients with stroke and Alzheimer’s disease. The present study was performed t...

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Bibliographic Details
Main Authors: Zhan Zhao, Ling Zhang, Xu-Dong Guo, Lu-Lu Cao, Teng-Fei Xue, Xiao-Jie Zhao, Dan-Dan Yang, Jin Yang, Juan Ji, Ji-Ye Huang, Xiu-Lan Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
PPARγ
rosiglitazone
depression
neuron
astrocyte
autophagy
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00293/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00293/full

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