Transcription Factor EBF1 Over-Expression Suppresses Tumor Growth in vivo and in vitro via Modulation of the PNO1/p53 Pathway in Colorectal Cancer

Transcription Factor EBF1 Over-Expression Suppresses Tumor Growth in vivo and in vitro via Modulation of the PNO1/p53 Pathway in Colorectal Cancer

Early B cell factor 1 (EBF1) has been identified as an upstream transcription factor of the potential oncogene PNO1 and is involved in the growth of colorectal cancer (CRC) cells. However, its expression, biological function, and underlying mechanism of action in most solid tumors remain largely unk...

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Bibliographic Details
Main Authors: Zhiqing Shen, Youqin Chen, Li Li, Liya Liu, Meizhong Peng, Xiaoping Chen, Xiangyan Wu, Thomas J. Sferra, Meizhu Wu, Xiaoying Lin, Ying Cheng, Jianfeng Chu, Aling Shen, Jun Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
EBF1
colorectal cancer
survival
tumor growth
PNO1
p53 pathway
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01035/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01035/full

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