Mesenchymal Stem Cell Therapy for Doxorubicin-Induced Cardiomyopathy: Potential Mechanisms, Governing Factors, and Implications of the Heart Stem Cell Debate

Mesenchymal Stem Cell Therapy for Doxorubicin-Induced Cardiomyopathy: Potential Mechanisms, Governing Factors, and Implications of the Heart Stem Cell Debate

Over the past decades, researchers have reported several mechanisms for doxorubicin (DOX)-induced cardiomyopathy, including oxidative stress, inflammation, and apoptosis. Another mechanism that has been suggested is that DOX interferes with the cell cycle and induces oxidative stress in C-kit+ cells...

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Bibliographic Details
Main Authors: Abdelrahman Ibrahim Abushouk, Amr Muhammad Abdo Salem, Anas Saad, Ahmed M. Afifi, Abdelrahman Yousry Afify, Hesham Afify, Hazem S.E. Salem, Esraa Ghanem, Mohamed M. Abdel-Daim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
anthracyclines
cardiac progenitor cells
cardiomyopathy
doxorubicin
mesenchymal stem cells
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00635/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00635/full

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