IL-6 blockade in systemic juvenile idiopathic arthritis – achievement of inactive disease and remission (data from the German AID-registry)

IL-6 blockade in systemic juvenile idiopathic arthritis – achievement of inactive disease and remission (data from the German AID-registry)

Abstract Background Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with an autoinflammatory component of unknown etiology related to the innate immune system. A major role in the pathogenesis has been ascribed to proinflammatory cytokines like interleukin-6 (IL-6), and effective...

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Main Authors: M. Bielak, E. Husmann, N. Weyandt, J.-P. Haas, B. Hügle, G. Horneff, U. Neudorf, T. Lutz, E. Lilienthal, T. Kallinich, K. Tenbrock, R. Berendes, T. Niehues, H. Wittkowski, E. Weißbarth-Riedel, G. Heubner, P. Oommen, J. Klotsche, Dirk Foell, E. Lainka
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Pediatric Rheumatology Online Journal
Subjects:
Systemic juvenile idiopathic arthritis
Autoinflammatory disease
Proinflammatory cytokines
Interleukin-6
Tocilizumab
Online Access:http://link.springer.com/article/10.1186/s12969-018-0236-y

Internet

http://link.springer.com/article/10.1186/s12969-018-0236-y

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