The CXCL12/CXCR4 Signaling Axis Retains Neutrophils at Inflammatory Sites in Zebrafish

The CXCL12/CXCR4 Signaling Axis Retains Neutrophils at Inflammatory Sites in Zebrafish

The inappropriate retention of neutrophils at inflammatory sites is a major driver of the excessive tissue damage characteristic of respiratory inflammatory diseases including COPD, ARDS, and cystic fibrosis. The molecular programmes which orchestrate neutrophil recruitment to inflammatory sites thr...

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Bibliographic Details
Main Authors: Hannah M. Isles, Kimberly D. Herman, Anne L. Robertson, Catherine A. Loynes, Lynne R. Prince, Philip M. Elks, Stephen A. Renshaw
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
neutrophil
inflammation
chemokine
retention
CXCR4
CXCL12
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01784/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01784/full

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