Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy.

Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy.

Fibroblast growth factors (FGFs) and their receptors are highly conserved signaling molecules that have been implicated in postnatal cardiac remodeling. However, it is not known whether cardiomyocyte-expressed FGF receptors are necessary or sufficient for ventricular remodeling in the adult heart. T...

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Bibliographic Details
Main Authors: Sarah N Cilvik, Joy I Wang, Kory J Lavine, Keita Uchida, Angela Castro, Carolyn M Gierasch, Carla J Weinheimer, Stacey L House, Attila Kovacs, Colin G Nichols, David M Ornitz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3859602?pdf=render

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http://europepmc.org/articles/PMC3859602?pdf=render

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