An inherent T cell deficit in healthy males to C. neoformans infection may begin to explain the sex susceptibility in incidence of cryptococcosis

An inherent T cell deficit in healthy males to C. neoformans infection may begin to explain the sex susceptibility in incidence of cryptococcosis

Abstract Background Cryptococcus neoformans, the causative agent of cryptococcosis, causes ~ 181,000 deaths annually, with males having a higher incidence of disease than females (7M:3F). The reason for this sex bias remains unclear. We hypothesized that this disparity was due to biological differen...

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Bibliographic Details
Main Authors: Tiffany E. Guess, Joseph Rosen, Natalia Castro-Lopez, Floyd L. Wormley, Erin E. McClelland
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Biology of Sex Differences
Subjects:
Cryptococcus neoformans
Cryptococcosis
Immune response
Sex bias in infection
T cells
B cells
Online Access:http://link.springer.com/article/10.1186/s13293-019-0258-2

Internet

http://link.springer.com/article/10.1186/s13293-019-0258-2

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