B4G2 Induces Mitochondrial Apoptosis by the ROS-Mediated Opening of Ca2+-Dependent Permeability Transition Pores

B4G2 Induces Mitochondrial Apoptosis by the ROS-Mediated Opening of Ca2+-Dependent Permeability Transition Pores

Background/Aims: Hepatocellular carcinoma (HCC) is the most common type of liver cancer. At present, only sorafenib is approved to treat HCC. In this study, we found that a 23-hydroxybetulinic acid derivative, B4G2, exhibited potent antiproliferative activity in HCC cell lines. Methods: We used four...

Full description

Bibliographic Details
Main Authors: Nan Yao, Ying-Jie Li, Dong-Mei Zhang, Dao-Lu Liu, Ming-Kuen Tang, Anita Yiu, Yong Li, Wei-Min Chen, Ping Lan, Zhe Yao, Zhe-Sheng Chen, Wen-Cai Ye
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
23-hydroxybetulinic acid derivative
HepG2 cells
PT pore
Mitochondrial pathway
ROS
Online Access:http://www.karger.com/Article/FullText/430212

Internet

http://www.karger.com/Article/FullText/430212

Similar Items