Newcastle Disease Virus (NDV) Oncolytic Activity in Human Glioma Tumors Is Dependent on CDKN2A-Type I IFN Gene Cluster Codeletion

Newcastle Disease Virus (NDV) Oncolytic Activity in Human Glioma Tumors Is Dependent on CDKN2A-Type I IFN Gene Cluster Codeletion

Glioblastoma (GBM) is the most aggressive and frequent primary brain tumor in adults with a median overall survival of 15 months. Tumor recurrence and poor prognosis are related to cancer stem cells (CSCs), which drive resistance to therapies. A common characteristic in GBM is <i>CDKN2A</i&...

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Bibliographic Details
Main Authors: Noemi García-Romero, Irina Palacín-Aliana, Susana Esteban-Rubio, Rodrigo Madurga, Sergio Rius-Rocabert, Josefa Carrión-Navarro, Jesús Presa, Sara Cuadrado-Castano, Pilar Sánchez-Gómez, Adolfo García-Sastre, Estanislao Nistal-Villan, Angel Ayuso-Sacido
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
glioblastoma
oncolytic virotherapy
Newcastle disease virus (NDV)
Interferon I
Online Access:https://www.mdpi.com/2073-4409/9/6/1405

Internet

https://www.mdpi.com/2073-4409/9/6/1405

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