Major Roles for Pyrimidine Dimers, Nucleotide Excision Repair, and ATR in the Alternative Splicing Response to UV Irradiation

Major Roles for Pyrimidine Dimers, Nucleotide Excision Repair, and ATR in the Alternative Splicing Response to UV Irradiation

We have previously found that UV irradiation promotes RNA polymerase II (RNAPII) hyperphosphorylation and subsequent changes in alternative splicing (AS). We show now that UV-induced DNA damage is not only necessary but sufficient to trigger the AS response and that photolyase-mediated removal of th...

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Bibliographic Details
Main Authors: Manuel J. Muñoz, Nicolás Nieto Moreno, Luciana E. Giono, Adrián E. Cambindo Botto, Gwendal Dujardin, Giulia Bastianello, Stefania Lavore, Antonio Torres-Méndez, Carlos F.M. Menck, Benjamin J. Blencowe, Manuel Irimia, Marco Foiani, Alberto R. Kornblihtt
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
UV irradiation
DNA damage
alternative splicing
nucleotide excision repair
global genome repair
cyclobutane pyrimidine dimers
Potorous photolyase
ATR
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302814

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http://www.sciencedirect.com/science/article/pii/S2211124717302814

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