CRISPR Interference–Potential Application in Retinal Disease

CRISPR Interference–Potential Application in Retinal Disease

The treatment of dominantly inherited retinal diseases requires silencing of the pathogenic allele. RNA interference to suppress gene expression suffers from wide-spread off-target effects, while CRISPR-mediated gene disruption creates permanent changes in the genome. CRISPR interference uses a cata...

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Bibliographic Details
Main Authors: Caroline F. Peddle, Lewis E. Fry, Michelle E. McClements, Robert E. MacLaren
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
CRISPR interference
CRISPRi
CRISPR/Cas9
RNAi
knock-down
gene therapy
Online Access:https://www.mdpi.com/1422-0067/21/7/2329

Internet

https://www.mdpi.com/1422-0067/21/7/2329

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