Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis

Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis

Abstract Background Idiopathic pulmonary fibrosis (IPF) is an age-related, progressive and lethal disease, whose pathogenesis is associated with fibroblasts/myofibroblasts foci that produce excessive extracellular matrix accumulation in lung parenchyma. Hypoxia has been described as a determinant fa...

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Bibliographic Details
Main Authors: Arnoldo Aquino-Gálvez, Georgina González-Ávila, Laura Lorena Jiménez-Sánchez, Héctor Aquiles Maldonado-Martínez, José Cisneros, Fernanda Toscano-Marquez, Manuel Castillejos-López, Luz María Torres-Espíndola, Rafael Velázquez-Cruz, Víctor Hugo Olivera Rodríguez, Edgar Flores-Soto, Héctor Solís-Chagoyán, Carlos Cabello, Joaquín Zúñiga, Yair Romero
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Respiratory Research
Subjects:
Hypoxia inducible factors; αSMA
Lung fibroblasts
HIF-1α
HIF-2α
HIF-3α
Methylation
Online Access:http://link.springer.com/article/10.1186/s12931-019-1100-4

Internet

http://link.springer.com/article/10.1186/s12931-019-1100-4

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