AMPK/mTOR Signaling in Autophagy Regulation During Cisplatin-Induced Acute Kidney Injury

AMPK/mTOR Signaling in Autophagy Regulation During Cisplatin-Induced Acute Kidney Injury

Autophagy is a conserved, multistep pathway that degrades and recycles dysfunctional organelles and macromolecules to maintain cellular homeostasis. Mammalian target of rapamycin (mTOR) and adenosine-monophosphate activated-protein kinase (AMPK) are major negative and positive regulators of autophag...

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Bibliographic Details
Main Authors: Ying Wang, Zhiwen Liu, Shaoqun Shu, Juan Cai, Chengyuan Tang, Zheng Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Physiology
Subjects:
cisplatin
acute kidney injury
nephrotoxicity
autophagy
AMPK
mTOR
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.619730/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.619730/full

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